WebNov 19, 2024 · An extracellular enzyme, ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1), hydrolyzes cGAMP and negatively regulates this anti-cancer immune response. Small-molecule ENPP1 inhibitors are much needed as tools to study the basic biology of extracellular cGAMP and as investigational cancer immunotherapy … WebThe protein encoded by this gene functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis.
5167 - Gene ResultENPP1 ectonucleotide pyrophosphatase ...
WebBackground: ENPP1 is expressed in precursor cells, but the role of ENPP1 in these cells is unknown.Results: High cellular ENPP1 expression promotes osteoblast (bone cell) differentiation, whereas low ENPP1 expression … WebEctonucleotide pyrophosphate-phosphodiesterase (enpp) conjugates and uses thereof WO2024140001A1 (en) * 2024-12-28: 2024-07-02: Riboscience Llc: Quinazoline derivatives as ectonucleotide pyrophosphatase phosphodiesterase 1 inhibitors WO2024240912A1 (en) * 2024-03-19: 2024-09-24: Stingray Therapeutics, Inc. lutheran sermons on 1 corinthians 13:1-13
Ectonucleotide Pyrophosphatase/Phosphodiesterase 1
WebJan 17, 2024 · Ectonucleotide Pyrophosphatase Phosphodiesterase Family Member 2 - Pipeline Review, H2 2024 - ResearchAndMarkets.com January 17, 2024 08:48 AM Eastern Standard Time WebHighly Selective and Potent Ectonucleotide Pyrophosphatase-1 (NPP1) Inhibitors Based on Uridine 5′-Pα,α-Dithiophosphate Analogues. Journal of Medicinal Chemistry 2024, 61 … WebSep 23, 2008 · Induction. Up-regulated by stimulation by allergen or by cross-linking with IgE. The IgE-mediated activation is enhanced by tetradecanoyl phorbol acetate (TPA), a stimulator of the PKC pathway, and inhibited by the P13 kinase inhibitors, LY294002 and wortmannin. Up-regulated in invasive bile duct cancers. lutheran sermons on luke 23