WebDayquil is active in the system for 4-6 hours depending on individual health variables. … WebIt's always best to follow the directions for dosing, but according to Harvard, "It's safest to take only what you need, and to not exceed 3,000 mg a day whenever possible, especially if you use acetaminophen often.". A dose of Niquil/Dayquil, if memory serves, is 1,000mg of acetaminophen. Approaching the daily limit in the span of 3ish hours ...
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