Tsc2 autophagy
WebNov 14, 2024 · These results suggest that SAL induced autophagy through the AMPK/TSC2/mTOR pathway and protected against neural injury. There have been some … WebWe have identified a cytoplasmic function for ATM that participates in the cellular damage response to ROS. We show that in response to elevated ROS, ATM activates the TSC2 …
Tsc2 autophagy
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WebMay 10, 2012 · Author Summary Tuberculosis is responsible for approximately 2 million deaths worldwide each year. Current treatment regimens require administration of … WebJul 14, 2024 · Autophagy is a cellular process involved in the selective degradation and recycling of dysfunctional intracellular components. It plays a crucial role in maintaining …
WebThe serine/threonine kinase ULK1, like its yeast homologue Atg1, is a key initiator of autophagy that is negatively regulated by the mTOR kinase. However, the molecular … WebApr 7, 2024 · Olaquindox, a feed additive, has drawn public attention due to its potential mutagenicity, genotoxicity, hepatoxicity and nephrotoxicity. The purpose of this study was …
WebJan 5, 2024 · Autophagy is a multi-step catabolic process that delivers cellular components to lysosomes for degradation and recycling. The dysregulation of this precisely controlled process disrupts cellular homeostasis and leads to many pathophysiological conditions. The mechanistic target of rapamycin (mTOR) is a central nutrient sensor that integrates … WebDownregulation of TSC2 (tuberous sclerosis 2) by EZH2 elicited MTOR activation, which in turn modulated subsequent MTOR pathway-related events, including inhibition of …
WebThe growth of animal skeletal muscle is mainly determined by the synthesis processes of total proteins in skeletal muscle cells, which has a significant impact on the postnatal …
WebOct 19, 2024 · Background Tuberous sclerosis complex (TSC) is a rare genetic multisystemic disorder resulting from autosomal dominant mutations in the TSC1 or TSC2 genes. It is characterised by hyperactivation of the mechanistic target of rapamycin complex 1 (mTORC1) pathway and has severe neurodevelopmental and neurological components … raines and rossWebThe regulation of ACTA2-AS1 to the cisplatin-resistant NSCLC cell autophagy was reversed by TSC2 increasing. Importantly, our results displayed that ACTA2-AS1 bound with EZH2, and TSC2 gene promoter combined with H3k27me3. The inhibition of ACTA2-AS1 to TSC2 expression was recused by EZH2 silencing. raines by totes automatic umbrellaWebOct 19, 2024 · Background Tuberous sclerosis complex (TSC) is a rare genetic multisystemic disorder resulting from autosomal dominant mutations in the TSC1 or … raines ave bakeryWebNov 11, 2024 · Autophagy inhibition by Spautin1, CQ or Atg7 KO reduced OCRs in Tsc2 KO MEFs (Fig. 2i,j and Extended Data Fig. 4m,n), consistent with reduced ATP (see Extended … raines bandWebApr 29, 2013 · These data identify a nitrosative-stress signaling pathway that engages ATM and the LKB1 and TSC2 tumor suppressors to repress mTORC1 and regulate autophagy. … rainesford stauffer ageWebIt has been well documented that cells deficient in either TSC1 or TSC2 are highly sensitive to various cell death stimuli. In this study, we utilized the TSC2 (-/-) mouse embryonic … raines farm wagyuWebApr 11, 2024 · Molecular analyses were performed and the tumor was found to harbor mutations in TP53 and TSC2, supporting a definitive diagnosis of malignant PEComa. The … raines bar \u0026 grill williamston sc